|
rs9943582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings demonstrate that allele A of rs9943582 was significantly associated with left ventricular systolic dysfunction, left ventricular end-diastolic diameter, the left atrial diameter and LVEF in the CAD population, which suggests an important role of the apelin/APJ system in the pathology of heart failure associated with ischemic heart disease.
|
25993436 |
2015 |
|
rs9939609
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
rs991104525
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients homozygous for the p.R152W mutation present a cardiac variant of MPS VI characterized by progressive cardiac valve disease leading to serious cardiac complications including abrupt death due to cardiac failure.
|
23633437 |
2013 |
|
rs9909004
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A recently discovered cardiac-specific regulatory variant for PRKCA (rs9909004) was independently associated with a decreased risk for all-cause mortality in patients with HF.
|
31728800 |
2019 |
|
rs9909004
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The haplotype carrying rs9909004 influences PRKCA expression in the heart and is associated with traits linked to heart failure, potentially affecting therapy of heart failure.
|
28120175 |
2017 |
|
rs9885413
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We identified and replicated an association for a genetic variant on chromosome 5q22 with 36% increased risk of death in subjects with heart failure (rs9885413, P = 2.7x10-9).
|
27149122 |
2016 |
|
rs9885413
|
|
T |
0.710 |
GeneticVariation |
GWASCAT |
We identified and replicated an association for a genetic variant on chromosome 5q22 with 36% increased risk of death in subjects with heart failure (rs9885413, P = 2.7x10-9).
|
27149122 |
2016 |
|
rs9838915
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The adjusted risk of heart failure hospitalization was 5.5-fold greater in those with LVH and the rs9838915 A allele compared to those without LVH and the GG genotype (hazard ratio (HR) 5.5 (1.6-18.6), P=0.006).
|
28400202 |
2017 |
|
rs964184
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
rs958546
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Six associations yielded p < 10(-5).The lowest p-values for each CVD trait were as follows: major CVD, rs499818, p = 6.6 x 10(-6); major CHD, rs2549513, p = 9.7 x 10(-6); AF, rs958546, p = 4.8 x 10(-6); HF: rs740363, p = 8.8 x 10(-6).
|
17903304 |
2007 |
|
rs9470398
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetics of heart rate in heart failure patients (GenHRate).
|
31113495 |
2019 |
|
rs9351814
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From these, rs10189761 and rs737337 variants were independently associated with HF prognosis (HR 2.295 (1.287-4.089, 95% CI); p = 0.005), whereas rs10423928, rs1800437, rs737337 and rs9351814 were related with bad prognosis only in obese patients (HR 2.142 (1.438-3.192, 95% CI); p = 0.00018).
|
31209632 |
2019 |
|
rs9303504
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cox proportional hazards models adjusted for established clinical risk factors and genomic ancestry tested the independent association of rs9909004 or rs9303504 and the variant interactions with cornerstone HF pharmacotherapies (beta-blockers or angiotensin-converting enzyme inhibitors/angiotensin receptor blockers) in additive genetic models.
|
31728800 |
2019 |
|
rs911119
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We used the common variant rs911119 in CST3 as an instrumental variable to investigate the causal role of cystatin C in CVD, including coronary heart disease, ischemic stroke, and heart failure.
|
27561768 |
2016 |
|
rs899115126
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ET-1 Lys198Asn and ET(A) receptor H323H polymorphisms seem to act synergistically to increase the risk of HF.
|
16582543 |
2006 |
|
rs8193037
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, we investigated whether common polymorphisms of genes IL17A and IL17RA (coding interleukin 17 receptor A) contribute to genetic predisposition to heart failure and adverse clinical outcomes associated with it.A total of 1713 adult patients with congestive heart failure and 1713 age- and sex-matched controls were genotyped for promoter single nucleotide polymorphisms (SNPs), rs2275913 and rs8193037 in IL17A and rs4819554 in IL17RA, to assess the relationship between individual SNPs and the risk of congestive heart failure.
|
27399111 |
2016 |
|
rs8179090
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, 300 HF outpatients with reduced left ventricular ejection fraction and 304 healthy blood donors were genotyped for the 372 T > C polymorphism (Phe124Phe; rs4898) in the TIMP-1 gene and the -418 G > C polymorphism (rs8179090) in the TIMP-2 gene to investigate whether these polymorphisms are associated with HF susceptibility and prognosis.
|
29930267 |
2018 |
|
rs8105292
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetics of heart rate in heart failure patients (GenHRate).
|
31113495 |
2019 |
|
rs8082812
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
rs799165
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
rs79661299
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetics of heart rate in heart failure patients (GenHRate).
|
31113495 |
2019 |
|
rs7965830
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetics of heart rate in heart failure patients (GenHRate).
|
31113495 |
2019 |
|
rs78314028
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetics of heart rate in heart failure patients (GenHRate).
|
31113495 |
2019 |
|
rs780094
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
rs7703051
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |